Following President Biden’s recent announcement regarding an imminent Emergency Temporary Standard (ETS) from OSHA, there are more questions about COVID-19 vaccine mandates than ever. The ETS will require employers with 100 or more employees to mandate COVID-19 vaccinations or weekly testing for employees. With this development, the number of requests for medical- and religious-based accommodations will likely rise. This Legal Quick Hit will cover these developments, discuss anticipated legal challenges to the Biden administration’s mandate, and provide best practices for medical and religious accommodation requests.